TF and chronic kidney disease: Recent research highlights neutrophil extracellular traps (NETs) as critical mediators of vascular damage and pro-calcific processes.<h4>Methods</h4>We obtained transcriptomic data from the NCBI GEO database for CKD rodent models and identified differentially expressed genes, selected genes using machine learning, functional enrichment, profiling of immune infiltration, transcription factor (TF) activity prediction and drug-gene interaction analysis.<h4>Results</h4>Our analysis revealed 36 NET-related genes with differential expression, and 19 were confirmed by the RobustRankAggreg method.