In a study of 28 youth with obesity (mean age: 13 years), half of them were insulin‐resistant while the other half were insulin‐sensitive, the insulin‐resistant group exhibited higher abdominal adiposity, despite being matched for body composition suggesting a specific link between increased abdominal fat and the early development of insulin resistance [25]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.