SP5 and Infertility: Several CGI-associated chromatin components (e.g., NRF1, SP5) have already been implicated in infertility and spermatogenesis defects (Wang et al, 2017; Xu et al, 2022), highlighting the potential relevance of CGI chromatin for intergenerational epigenetic transmission (Molaro et al, 2011), though the full extent of this phenomenon remains to be determined.