In addition to being classical players in type 2 responses, e.g., Th2 lymphocytes, ILC2s, eosinophils, and mast cells, type 2 CD8+ cytotoxic cells produce type 2 cytokines in response to IL-33 in experimental allergic airway inflammation, as well as in severe asthma and asthma exacerbations in patients [279]. The gene discussed is IL33; the disease is asthma.