For example, mutations in proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1), which increases its binding to pyrin, promote excessive inflammasome activation and result in pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome [264, 265]. The gene discussed is PSTPIP1; the disease is pyoderma gangrenosum.