In sepsis patients, IL-1R2 is associated with a cluster of monocytes characterized by low levels of HLA-DR and limited TNF production [69], as well as by the coexpression of mature macrophages and immune dysfunction features, which correlate with immunological markers and clinical parameters (e.g., SOFA score, creatinine, survival), reflecting infection severity [73]. This evidence concerns the gene IL1R2 and Sepsis.