Indeed kidney-specific deletion of either Flcn (93, 94) or both members of its associated complex, Fnip1 and Finp2 (95), results in renal cystic disease associated with constitutive Tfeb nuclear localization and alterations in mTORC activity, which in Flcn KO mice is completely rescued in the context of Tfeb KO (96). This evidence concerns the gene TFEB and cystic kidney disease.