PKD2 and autosomal dominant polycystic kidney disease: Here, we characterize the protein interaction networks of PC1 and PC2 in cycling and ciliated cells using proximity-dependent biotinylation (BioID), identifying a common set of 172 proteins that interact with the C terminus of PC1 and the full-length PC2 protein, enriched in autophagy regulators, endoplasmic reticulum tethers, endoplasmic reticulum stress proteins, and other proteins previously linked to ADPKD.