Furthermore, we also demonstrate that WE-CL13-GP181M-185W-492I induces more pronounced tumor regression in the lung adenocarcinoma (Eml4-Alk) model compared to the recombinant unmutated strain WE-CL13 (Figure 5B), clearly demonstrating the enhancement of anti-tumoral effects upon introduction of selected mutations affecting increased tumor cell infection. The gene discussed is ALK; the disease is infection.