Our previous studies have shown that the inhibition of Collapsin response mediator protein 2 (CRMP2) phosphorylation suppresses inflammation and ameliorates pathological progression in spinal cord injury and MPTP-induced Parkinson’s disease models using CRMP2KI/KI mice, in which the phosphorylation site Ser522 was replaced with Ala. The gene discussed is DPYSL2; the disease is Parkinson disease.