In contrast, Tau Tg; CRMP2 KI/KI neurons partially recovered from this deficit; their intersection curve rose closer to that of WT (****p < 0.0001), especially at the critical 6–12 μm range, demonstrating that preventing CRMP2 phosphorylation mitigates Tau-induced dendritic atrophy (***p < 0.001). Here, DPYSL2 is linked to Atrophy.