Notably, alcohol consumption and cigarette smoking are major risk factors for both malignancies.19,20 Aldehyde dehydrogenase 2 dysfunction is reported to be associated with tumorigenesis in the both cancers.21,22 Similarly, breast cancer gene 2 mutation is associated with both cancers.23,24 Genetic associations between PDAC and esophageal cancer warrant further investigation in future studies. Here, ENSG00000280371 is linked to cancer.