Among the list of EWSR1::FLI1-KDM6A–activated targets, we found CDH11, IRS2, and SYT1 (Fig. 3G and H; Supplementary Fig. S3E), whereas for EWSR1::FLI1-KDM6B, we found targets such as IGF1, MMP9, and JARID2, previously described in Ewing sarcoma (Fig. 3G and I; Supplementary Fig. S3F). This evidence concerns the gene IRS2 and Ewing sarcoma.