EWSR1 and Ewing sarcoma: Although, in hpMSCs, overexpression of EWSR1::FLI1 remodels the chromatin landscape by redistributing H3K27me3, in Ewing sarcoma cell lines, depletion of KDM6B—but not KDM6A—exerts its main effects partly by restoring H3K27me3 levels at enhancers.