Interestingly, SNPs within DORs that appear upon IFN-γ stimulation are more often associated with immune diseases and immune phenotypes such as systemic lupus erythematosus (SLE) (Fig. 6(E)), COVID-19 (Fig. 6(D)), autoimmune diseases (Fig. 6(E)), and response to vaccines (Fig. 6(F)). This evidence concerns the gene IFNG and autoimmune disease.