Notably, Rho signaling via ROCK has previously been shown to activate the PI3K/ protein kinase B (Akt) pathway, thereby promoting melanoma progression.[96] These findings indicate that ROCK1/2 may mediate the pro‐metastasis effects of GCs.[97] As a crucial intervention for irAEs, further investigation into their potential contributions and mechanisms to melanoma metastasis is required. Here, RHO is linked to melanoma.