This was characterized by epinephrine‐dependent mobilization of NK cells into circulation and IL‐6‐dependent recruitment to tumor sites.[259] In another study, exercise suppressed tumor growth and enhanced CD8+ T cell infiltration in YUMMER murine melanoma models.[260] These exercise‐induced metabolic reprogramming has been proposed to increase systemic nutritional demands—such as catabolic activity, glucose uptake, mitochondrial function, and GLUT expression—thereby creating metabolic competition that restricts nutrient availability to tumors and forms a metabolic barrier around them.[261]. This evidence concerns the gene CD8A and melanoma.