AXL and melanoma: For instance, the most up‐to‐date research reveals that male aging drives a uniquely aggressive and therapy‐resistant TME through fibroblast‐mediated AXL/BMP2 signaling.[82] By highlighting the combined effects of sex and age on melanoma, these findings underscore the importance of integrating multi‐omics data in future research to unravel the molecular mechanisms underlying these complex interactions.