NONO and melanoma: Notable concentrations of 15d‐PGJ2 have been detected in the culture medium of melanoma cells, sufficient to activate caspase‐8 and the mitochondrial apoptosis pathway.[148] Simvastatin also significantly downregulated NonO gene expression, a vital growth factor involved in splicing regulation.[149] These results may account for the reduced proliferation of melanoma cells, suggesting a potential mechanism of action.