Moreover, the expression of Cpt1a, a key gene in FAO, was elevated in the tumor tissues and CD8+ T cells of DIO mice.[214] Cpt1a has been identified as upregulated in the early stages of T cell exhaustion and is considered a potential driver of metabolic reprogramming exhaustion with this phenotype.[215] Inhibition of PPARα/δ or blockade of mitochondrial lipid transport restored NK cell cytotoxicity.[216]. The gene discussed is CD8A; the disease is neoplasm.