For instance, a preclinical study indicated that cyclic fasting increased the susceptibility of melanomas in mice to the chemotherapeutic agent Adriamycin.[229] In animal models, intermittent fasting also reduced the melanoma growth and enhanced susceptibility to the targeted medication sorafenib.[230] Additionally, periodic fasting‐mimicking diet (FMD) cycles, either administered alone or in conjunction with anti‐OX40 or anti‐programmed death‐ligand 1 (PD‐L1) agents, have demonstrated significantly greater efficacy than ICIs alone in inhibiting melanoma growth in murine models. Here, TNFRSF4 is linked to melanoma.