STAMBP and melanoma: Upon UVR exposure, surviving keratinocytes secrete melanocyte growth including α‐melanocyte‐stimulating hormone (α‐MSH) and Endothelin‐1, which stimulate both cytokine and melanin production.[330] In addition, direct and indirect interactions between melanoma cells and surrounding keratinocytes or fibroblasts can influence melanoma cell behavior and metastatic potential.[331, 332] Concurrently, UVR modulates the activity of immune cells within the TME.