Depletion of leptin in adipocytes or knockdown of OB‐Rb in melanoma cells using siRNA abrogated Akt and ERK activation, cell proliferation, and drug resistance.[210] Ad‐EVs convey β‐catenin protein to melanoma cells, where it accumulates in the nucleus and suppresses CDKN2A expression, reducing p16INK4A protein and enhancing cell motility. The gene discussed is LEP; the disease is melanoma.