IGFBP2 and melanoma: When exposed to the lipid secretome of aged fibroblasts or cocultured with them, melanoma cells exhibit increased lipid uptake via the fatty acid transport protein 2 (FATP2), which is upregulated in melanoma cells within the aged TME and is known to play a role in lipid synthesis and accumulation.[79] In parallel, aged fibroblasts secrete insulin‐like growth factor binding protein 2 (IGFBP2), which triggers the upregulation of the phosphoinositide 3‐kinase (PI3K)‐dependent fatty acid biosynthesis program in melanoma cells, thereby enhancing tumor invasiveness.[80]