While direct evidence connecting circadian regulators to DNA repair in melanoma remains limited, circadian transcription factors have been implicated in modulating key DNA repair genes—such as BRCA1 and RAD50—in other cancers, including breast cancer,[358] colorectal cancer,[359] and hepatocellular carcinoma.[360] These findings support the hypothesis that the circadian clock may influence melanoma pathogenesis via regulation of DNA repair pathways, though further mechanistic studies are needed to define this axis more precisely in melanoma. This evidence concerns the gene RAD50 and melanoma.