For instance, the combination of exercise and anti‐PD‐1 therapy increased the percentage of CD8+ T cells in mice with EO771 breast tumor‐bearing mice, but not in mice with B16F10 melanoma.[257] Conversely, another study demonstrated that exercise exerted evident anti‐tumor effects and favorable biosafety in the B16F10 homograft malignant melanoma model, primarily by alleviating hypoxia and enhancing tumor immune infiltration within the tumor.[258]. This evidence concerns the gene CD8A and neoplasm.