APOE and early-onset autosomal dominant Alzheimer disease: Recent studies suggest that the differential effects of APOE alleles on amyloid‐β accumulation and neuroinflammation are key to understanding their roles in Alzheimer's disease pathology.[11] However, the specific role of APOE in epilepsy remains poorly understood, particularly regarding its involvement in microglial regulation of neuroinflammation and neuronal damage during epilepsy progression.