TNF and epilepsy: Animal studies have demonstrated that cGAS activation can drive microglia into an aging‐associated activated state, affecting neuronal survival through inflammatory cytokine secretion, particularly TNF.[41] Inhibiting the cGAS‐STING pathway can alleviate hippocampal neuronal apoptosis and slow epilepsy progression.[42] However, the current research on the relationship between the cGAS‐STING pathway and neuronal excitability remains limited.