Recent studies suggest that the differential effects of APOE alleles on amyloid‐β accumulation and neuroinflammation are key to understanding their roles in Alzheimer's disease pathology.[11] However, the specific role of APOE in epilepsy remains poorly understood, particularly regarding its involvement in microglial regulation of neuroinflammation and neuronal damage during epilepsy progression. This evidence concerns the gene APOE and epilepsy.