The role of TGFβ in IDD has been previously explored, with studies showing that TGFβ signaling can promote ECM synthesis and inhibit NP cells apoptosis.[65, 66] Our results extend this knowledge by demonstrating that TGFβ signaling is enhanced through the PSAP‐GPR37 axis. The gene discussed is GPR37; the disease is intervertebral disk degenerative disorder.