Importantly, our findings align with recent reports highlighting SIRT1/FoxO3a as a central hub for resolving immune‐metabolic dysfunction in arthritis or hypoxia‐ischemia brain injury,[64, 65] yet uniquely extend this paradigm to infectious contexts by demonstrating punicalagin's dual capacity to reinforce mitochondrial resilience and reinvigorate host autophagy to facilitate pathogen clearance. This evidence concerns the gene FOXO3 and brain injury.