Notably, SIRT1 knockdown via si‐SIRT1 further aggravated MAB infection, as evidenced by the inability of THP‐1 cells to restrict intracellular MAB proliferation shown by increased amount of GFP‐labeled MAB (Figure 5a), significantly impaired autophagy function in macrophages, ultimately leading to cell death and exacerbation of infection as evidenced by increased nuclear fragmentation (Figure 5c, third row). Here, SIRT1 is linked to infection.