Importantly, our findings align with recent reports highlighting SIRT1/FoxO3a as a central hub for resolving immune‐metabolic dysfunction in arthritis or hypoxia‐ischemia brain injury,[64, 65] yet uniquely extend this paradigm to infectious contexts by demonstrating punicalagin's dual capacity to reinforce mitochondrial resilience and reinvigorate host autophagy to facilitate pathogen clearance. The gene discussed is SIRT1; the disease is brain injury.