These pH homeostasis alterations are hypothesized to impact cellular functions such as protein degradation and redox balance, potentially contributing to the pathogenesis of various diseases, including Parkinson's disease(PD), Alzheimer's disease (AD), and Amyotrophic Lateral Sclerosis (ALS).[50, 51, 52] In recent years, the Hv1 channel has emerged as a critical therapeutic target in neurodegenerative diseases.[53, 54] Modulating Hv1 overactivity may induce neurodegeneration by perturbing intracellular pH homeostasis and cellular function. Here, HVCN1 is linked to amyotrophic lateral sclerosis.