In addition, pyrimidine metabolism is related to cell proliferation, and the key rate-limiting enzymes carbamoyl-phosphate synthetase 2, aspartate transcarbamylase and dihydroorotase (CAD) and dihydroorate dehydrogenase (DHODH) in pyrimidine synthesis can promote the proliferation of various cancer cells (Yang et al, 2023). This evidence concerns the gene CAD and cancer.