With the continuous development of relevant research, GLDC has been found to be associated with the proliferation of various tumor cells, including breast cancer (Xie et al, 2022), neuroblastoma (Alptekin et al, 2019), gastric cancer (Min et al, 2016), lung cancer (Yuan et al, 2019), etc. In view of the above studies, it is of great value to further clarify the effect of GLDC in the occurrence and development of IgAN and explore its mechanism of regulating the proliferation of mesangial cells, which is of great value to search for therapeutic targets of IgAN in the future. The gene discussed is GLDC; the disease is gastric cancer.