Notably, a series of Parkinson’s disease (PD)-related genes linked to the endomembrane system, including VPS35, LRRK2, GBA, TMEM175 and VPS13C were also identified (Fig. 5c) indicating that PD proteins may act along the MAPL pathway to regulate immune signalling and cell death57. The gene discussed is TMEM175; the disease is Parkinson disease.