IL6 and systemic lupus erythematosus: 90 Upon bone marrow transplantation into naïve recipient mice, autoimmune-trained HSCs maintained epigenetic and functional trained immunity, while reverting metabolic alterations.90 Nuclear self-antigens such as apoptotic microparticles and neutrophil extracellular traps (NETs) isolated from the circulation of SLE patients can induce trained immunity in vitro.91 Trained immunity induced by nuclear antigens was linked to increased IL-6 responses in peripheral blood mononuclear cells (PBMCs) from non-flaring SLE patients.91