Risk factors for Alzheimer’s disease overlap with known factors causing maladaptive trained immunity, including brain trauma, periodontitis, obesity and systemic inflammation and infection.16,18,22,151,157 Similar to Alzheimer’s disease associated neuroinflammation, maladaptive central trained immunity associated with periodontitis, brain injury and western-like diet induced inflammation is induced by inflammasome signaling and IL-1β.16,18,22 Contributions of central and peripheral maladaptive trained immunity linking periodontitis and diet with AD remain to be studied. The gene discussed is IL1B; the disease is periodontitis.