BRCA1 and breast carcinoma: In a study conducted by van Barele et al. on patients with BRCA1/2 variant-associated breast cancer, smaller tumor sizes were correlated with improved 10 -year overall survival (OS) without chemotherapy, with rates of 90.8% for pT1bN0 and 77.1% for pT1cN0 (P = 0.02).26