Several statistical models can estimate breast cancer risks using the risk factors including a personal or family history of breast cancer, first-degree relative with breast or ovarian cancer, pathogenic variants (BRCA1, BRCA2, etc.), prior chest radiotherapy (ages 10–30), high-risk breast lesions (atypical ductal hyperplasia, atypical lobular hyperplasia, and lobular carcinoma in situ), personal hormone and reproductive history, and dense breast tissue.8 The gene discussed is BRCA1; the disease is breast cancer.