Several statistical models can estimate breast cancer risks using the risk factors including a personal or family history of breast cancer, first-degree relative with breast or ovarian cancer, pathogenic variants (BRCA1, BRCA2, etc.), prior chest radiotherapy (ages 10–30), high-risk breast lesions (atypical ductal hyperplasia, atypical lobular hyperplasia, and lobular carcinoma in situ), personal hormone and reproductive history, and dense breast tissue.8 This evidence concerns the gene BRCA2 and breast cancer.