<h4>Background</h4>To explore whether β-glucan combined with anti-PD-L1 reverses the immunosuppressive Tumor Microenvironment (TME) in residual pancreatic cancer after Microwave Ablation (MWA).<h4>Methods</h4>The effect of β-glucan on the activation of Dendritic Cells (DCs) was assessed in vitro. Here, CD274 is linked to familial pancreatic carcinoma.