In our prior research, we demonstrated that the TLR4/MyD88/NF‐κB pathway contributed to the pathogenesis of PPA.[51] Nevertheless, in the current study, we did not thoroughly investigate the functional significance of the NF‐κB signaling pathway with FOXC2, nor did we explore the potential therapeutic effect of AE mediated through the NF‐κB signaling pathway. This evidence concerns the gene NFKB1 and primary progressive aphasia.