IRF8 and neoplasm: For instance, pathways related to IL‐4 and IL‐13 signaling (IL4R, FOS, CEBPD, JUNB), which reinvigorate terminally exhausted intratumoral CD8+ T cells,[37] and those involved in regulated necrosis and interferon signaling (IFNG, GZMB, CASP4, IRF8, ISG20, IFITM1, IFITM3, GBP5), crucial for tumor restriction, were enriched in tumoral NK cells.