AREG and melanoma: To address this, we investigated AREG's biological role in human NK cells by engrafting NCG mice (NOD/ShiLtJGpt‐Prkdcem26Cd52Il2rgem26Cd22/Gpt) with human melanoma or cSCC cell lines and evaluating the tumor‐restricting effects of adoptively transferred WT or AREG KO human NK cells, expanded in NK MACS medium and stimulated with IL‐12+IL‐15+IL‐18 (Figure8A).