Transcriptomic analysis revealed that skin tumor NK cells exhibited dual functional features: anti‐tumor activity alongside elevated AREG expression, a cytokine that promotes keratinocyte/fibroblast proliferation and therapy resistance via EGFR signaling (Figure 2A,D).[27, 29, 30, 31, 46, 47] Flow cytometry confirmed this dichotomy, showing increased AREG production in tumor‐infiltrating NK cells compared to their peri‐tumor counterparts, while revealing concurrent downregulation of TNF‐α and preserved IFN‐γ production (Figure3A–D). Here, AREG is linked to skin neoplasm.