AREG and skin neoplasm: Tumor cells can regenerate active glucocorticoids via HSD11B1, thereby establishing a glucocorticoid‐enriched microenvironment.[75] Tumor stress also induces HSPs, known GR coactivators; consistent with this, we found HSPs upregulated in skin tumor NK cells (Figure 2A; Table S3, Supporting Information), and HSP90 inhibition impaired Dex‐induced AREG production (Figure 4N).