UBC and cancer: Conversely, pathways linked to tumor stress responses were also enriched, including the HSP90 chaperone cycle for steroid hormone receptors (HSPA1A, HSP90AA1, HSPA1B, DANJB1), which enhances glucocorticoid receptor activity and tumor resistance,[38, 39, 40, 41, 42, 43] and EGFR signaling in cancer (AREG, UBC, HSP90AA1), which promotes tumor progression[29, 44] (Figure 2A; Table S3, Supporting Information).