IFNG and neoplasm: Transcriptomic analysis revealed that skin tumor NK cells exhibited dual functional features: anti‐tumor activity alongside elevated AREG expression, a cytokine that promotes keratinocyte/fibroblast proliferation and therapy resistance via EGFR signaling (Figure 2A,D).[27, 29, 30, 31, 46, 47] Flow cytometry confirmed this dichotomy, showing increased AREG production in tumor‐infiltrating NK cells compared to their peri‐tumor counterparts, while revealing concurrent downregulation of TNF‐α and preserved IFN‐γ production (Figure3A–D).