A prior study demonstrated that 3‐HAA could attenuate atherosclerosis and improve plasma lipid metabolism, indicating its potential protective role in metabolic diseases.[42] Additionally, another study showed that 3‐HAA metabolism regulates hepatic sterol regulatory element‐binding protein‐2 (SREBP‐2) activity and inhibits inflammasome activation in macrophages.[43]. This evidence concerns the gene SREBF2 and Other metabolic disease.