MUC15 and cancer: Within the pancreatic tumor microenvironment, cancer‐associated fibroblasts (CAFs) play a crucial role in ECM remodeling and cancer cell invasion.[43, 44, 45, 46] Since our data showed that MUC15 regulates YAP (Figure 2), and because YAP's downstream target CTGF is a key activator of CAFs, we investigated this signaling axis.