The promotion of migration and invasion by MUC15 depletion contradicts the widespread reports of attenuation of cancer cell migration and invasion by glycocalyx downregulation.[22, 23] To identify the underlying pathway, we first investigated YAP, a downstream effector of the Hippo pathway whose activation promotes cell adhesion, migration, invasion, and tumor progression.[24] A potential role of YAP was supported by immunohistochemical staining of pancreatic cancer tissues, which showed increased nuclear localization of YAP in comparison to normal pancreatic tissues (Figure 2a). This evidence concerns the gene MUC15 and pancreatic neoplasm.