MUC15 and cancer: Larger focal adhesions, as observed in MUC15‐depleted Panc‐1 cells, are often associated with enhanced assembly of the actin cytoskeleton and with increased cellular contractility,[32, 33] both of which promote cancer cell migration and invasion through increased ECM remodeling.[34] Consistent with this, immunostaining of F‐actin showed that MUC15 depletion led to increased assembly of F‐actin (Figure 3c,d), while MUC15 overexpression had the opposite effect (Figure 3e,f).