MUC15 and neoplasm: The promotion of migration and invasion by MUC15 depletion contradicts the widespread reports of attenuation of cancer cell migration and invasion by glycocalyx downregulation.[22, 23] To identify the underlying pathway, we first investigated YAP, a downstream effector of the Hippo pathway whose activation promotes cell adhesion, migration, invasion, and tumor progression.[24] A potential role of YAP was supported by immunohistochemical staining of pancreatic cancer tissues, which showed increased nuclear localization of YAP in comparison to normal pancreatic tissues (Figure 2a).