PODXL and neoplasm: For example, overexpression or depletion of the glycoprotein podocalyxin has been shown to modulate E‐cadherin levels in a context‐dependent manner, with consequences for tumor growth and metastasis.[22] Moreover, glycoprotein CD44 mediates adhesion between tumor cells and endothelial cells by binding to deposited hyaluronic acid, thereby facilitating the trans‐endothelial migration and invasion.[52] The size‐dependent steric effects of glycoproteins proposed in our study may also influence cadherin‐based intercellular adhesions and, by extension, collective migration dynamics.