By co‐delivering Mn2+, CDDP, and the BRD4‐targeting PROTAC dBET6 within a tumor cell membrane‐camouflaged manganese metal‐organic framework, this platform achieves triple activation of the cGAS‐STING pathway via Mn2+‐induced immune sensing, nucleus DNA damage, and BRD4 degradation‐mediated mitochondrial dysfunction. This evidence concerns the gene STING1 and neoplasm.