In iron metabolism, BMP6‐mediated hepcidin regulation affects iron homeostasis, and iron overload promotes ferroptosis and oxidative stress, contributing to endothelial dysfunction.[20, 21] In tumors, BMP6 has been shown to modulate angiogenesis through VEGFR2 signaling and endothelial‐mesenchymal transition.[36] Extending upon these findings, the present study provides the first evidence of the role of BMP6 in the pathogenesis of atherosclerosis, particularly in vascular calcification. Here, KDR is linked to endothelial dysfunction.