HAMP and endothelial dysfunction: In iron metabolism, BMP6‐mediated hepcidin regulation affects iron homeostasis, and iron overload promotes ferroptosis and oxidative stress, contributing to endothelial dysfunction.[20, 21] In tumors, BMP6 has been shown to modulate angiogenesis through VEGFR2 signaling and endothelial‐mesenchymal transition.[36] Extending upon these findings, the present study provides the first evidence of the role of BMP6 in the pathogenesis of atherosclerosis, particularly in vascular calcification.