For instance, BMP9 regulates the osteoblastic differentiation of VSMCs in chronic kidney disease,[33] BMP2 mediates pro‐osteogenic reprogramming in aortic valve interstitial cells,[34] and BMP4 promotes the recruitment and activation of monocytes and macrophages, enhances foam cell formation, and affects inflammation and plaque stability.[35] Previous studies have indicated that BMP6 plays multifaceted roles in iron metabolism, tumor biology, and cardiovascular disease, all of which may collectively contribute to vascular dysfunction. This evidence concerns the gene BMP6 and neoplasm.