Next, supernatants from mice tumor lysates were analyzed by ELISA, and the results indicated that the concentrations of IFN‐γ, TNF‐α, Perforin and Granzyme B were higher in the anti‐PD‐L1 treatment group than in the isotype control IgG group, while circLRBA overexpression suppressed the secretion of these factors (Figure 10D–G). This evidence concerns the gene TNF and neoplasm.