PRF1 and neoplasm: Next, supernatants from mice tumor lysates were analyzed by ELISA, and the results indicated that the concentrations of IFN‐γ, TNF‐α, Perforin and Granzyme B were higher in the anti‐PD‐L1 treatment group than in the isotype control IgG group, while circLRBA overexpression suppressed the secretion of these factors (Figure 10D–G).