reported that circGSK3β facilitates PD‐L1 transcription and immune evasion in BC via the miR‐338‐3p/PRMT5/H3K4me3 axis.[35] In our study, circLRBA could competitively bind to the E3 ubiquitin ligase SPOP to inhibit the interaction between SPOP and Twist1 and the degradation of Twist1. Here, CD274 is linked to breast cancer.