FOXP2 and obesity due to melanocortin 4 receptor deficiency: In this context, changes in methylation at single CpGs within FOXP2 (cg26580413) were correlated with changes in weight (FOXP2, R = 0.85), and copy number variants in FOXP2 have been associated with childhood obesity and nominally associated with obesity in a familial case−control study [64, 65].