The clarification of the interplay between SDH dysfunction, succinate accumulation, and immunogenicity specifically in UPS is thus crucial as the microenvironmental immune composition of UPS was shown to have prognostic value (denser infiltration by CD8+ T lymphocytes and monocytes is associated with significantly better survival outcomes; refs. 45, 46), and the intracellular succinate levels of both tumor cells and microenvironmental CD8+ T cells are known to be linked to different profiles of antitumor immunogenicity (47). The gene discussed is SDHB; the disease is neoplasm.