Figure 8C, 8D provided the profile of homozygous and heterozygous CNV of hub genes in prostate cancer. The results of methylation analysis indicated that the methylation level of these genes were generally up-regulated in tumor prostate tissues compared to normal tissues (Figure 9A). For example, the methylation level of CPA6 was higher in tumor tissues. In addition, methylation level of CPA6 was negatively linked to its mRNA expression (Figure 9B). Here, CPA6 is linked to Familial prostate cancer.