Numerous genes are differentially methylated in the AD brain, such as ANK1, BIN1, ABCA7, and HOXA, as well as amyloidogenic pathway genes APP and PSEN1 (De Jager et al. 2014; Fetahu et al. 2019; Gasparoni et al. 2018; Lunnon et al. 2014; Semick et al. 2019; Smith et al. 2018, 2019). This evidence concerns the gene APP and Alzheimer disease.