Genes significantly associated with IBA1 staining belonged mainly to the microglial TYROBP network, as well as migration, adhesion, and cytokine production (Figure 5J), including genes within the complement pathway, such as C3, which is upregulated in human AD and required for neurodegeneration in mouse models (Wu et al. 2019) (Figure 5K, n = 112, Pearsons r = 0.46, FDR = 0.0009). Here, AIF1 is linked to Alzheimer disease.