Other studies reported that cyclin-dependent kinase 2 triggers the degradation of C/EBPα through SKP2 in acute myeloid leukemia (AML) (56), and that SKP2 ubiquitinates C/EBPα through physically interacting with the C-terminal portion of C/EBPα in AML (57). Here, CEBPA is linked to acute myeloid leukemia.