While many of the genes found in this study have been previously reported in NSCLC, such as CDK1, TOP2A, AURKA, TPX2, BUB1B, and CENPF, as well as PVT1 and miR-143–3p, our study offers new insights by combining multiple transcriptomic datasets, co-expression network analysis, and machine learning approaches. Here, CENPF is linked to non-small cell lung carcinoma.