Our recent studies have shown that DGKα preferentially generates saturated fatty acid (SFA)- and/or monounsaturated fatty acid (MUFA)-containing PAs, such as 16:0/16:0-, 16:0/16:1-, and 16:0/18:0-PA in AKI melanoma cells [44], whereas DGKδ selectively produces SFA- and/or MUFA-containing PAs, such as 14:0/16:0-, 14:0/16:1-, 16:0/16:0-, 16:0/16:1-, 16:0/18:0-, and 16:0/18:1-PAs in myoblasts [52]. The gene discussed is DGKA; the disease is acute kidney injury.