Another effective intervention aimed at reducing antimicrobial consumption, particularly in neonates, involved the early discontinuation of antibiotics in patients lacking evidence of infection risk factors.24 This included neonates who presented without clinical sepsis, had a C-reactive protein value ≤ 10 mg/L during the first 72 hours of life, and displayed negative cultures within the first three days of antibiotic therapy. Here, CRP is linked to infection.