<i>Rabdosia rubescens</i> was found to induce the expression of LC3, Beclin-1, and ATG7 proteins and mRNA, while inhibiting the expression of CYP7A1, SREBP, FAS, and p62 proteins and mRNA (<i>p</i> < 0.05 or <i>p</i> < 0.01).<h4>Conclusion</h4><i>Rabdosia rubescens</i> has been shown to relieve alcohol-induced liver damage in mice by reducing levels of CYP7A1, alleviating cholestasis and reducing inflammation. This evidence concerns the gene BECN1 and cholestasis.