APOE and early-onset autosomal dominant Alzheimer disease: We illustrate the method in simulation studies and an application to the Apolipoprotein E locus in a family-based association study of Alzheimer's Disease.<h4>Availability and implementation</h4>The fine-mapping approach FBAT DAP-G is implemented in the FBAT package https://github.com/FBATsw/FBAT/.