NLRP3 and early-onset autosomal dominant Alzheimer disease: Caspases are proteases involved in apoptosis and inflammation (Molla et al. 2020), and CASP‐1 is particularly well known as a major component of the NLRP3‐CASP1 inflammasome and a promising therapeutic target for Hutchinson‐Gilford progeria, another premature aging syndrome, and Alzheimer's disease (Heneka et al. 2013).