On the other hand, CP, or ceruloplasmin, is a copper‐binding glycoprotein involved in iron metabolism and defense against oxidative stress; decreased CP activity is associated with advanced age and age‐related diseases, such as Parkinson's and Alzheimer's disease (Semsei et al. 1993; Kristinsson et al. 2012; Wang and Wang 2019). The gene discussed is CP; the disease is early-onset autosomal dominant Alzheimer disease.