SPARC is expressed ubiquitously in mammalian tissues, particularly in adipocytes, and is involved in bone development and turnover and wound healing, especially in corneal tissue; SPARC KO mice have dysregulated collagen and suffer from osteopenia and cataracts (Rosset and Bradshaw 2016; Basu et al. 2001; Lin et al. 2023; Kos and Wilding 2010). The gene discussed is SPARC; the disease is Osteopenia.