EFEMP1, also known as fibulin‐3, is an ECM glycoprotein strongly associated with aging pathologies: overexpression contributes to age‐related macular degeneration, high plasma levels are associated with signs of brain aging and higher risk of dementia, and upregulation of this gene is associated with Werner syndrome, a premature aging condition (Cheng et al. 2020; McGrath et al. 2022). The gene discussed is EFEMP1; the disease is dementia.