Focusing on the NK‐cell–melanoma interaction, we identified three primary regulatory mechanisms: IFNγ, a cytokine secreted by NK‐cells that plays a crucial role in modulating melanoma cell responses [5], as well as CD99 and CRTAM, two surface proteins involved in cell adhesion [40, 41, 42] (Fig. 2E). This evidence concerns the gene CD99 and melanoma.