ERN1 and hepatocellular carcinoma: A study on hepatoma cells suggested that the tricarboxylic acid (TCA) cycle, a metabolic pathway downstream of glucose, could stimulate ER stress through Idh2‐mediated mitochondrial NADPH production and glutathione redox (Gansemer et al. 2020), indicating the possibility that glucose might activate Ire1‐Xbp1s activity through this TCA cycle‐mediated mechanism in N. furzeri skin.