Furthermore, we could demonstrate that VEXAS CD34+ cells exhibited significantly higher levels of apoptosis after treatment with TAK‐243 and pevonedistat compared to both MDS (TAK‐243: IC75 p = 0.0007; pevonedistat: IC25 p = 0.035, IC50 p = 0.0031, IC75 p = 0.0049) and healthy CD34+ cells (TAK‐243: IC50 p = 0.0005, IC75 p = 0.0004; pevonedistat: IC25 p = 0.0064, IC50 p = 0.0027, IC75 p = 0.0077) (Figure 1E,F). Here, CD34 is linked to myelodysplastic syndrome.