These included the DLD1 human colon cancer line with or without BRCA2 knockout (BRCA2KO or WT), as well as BRCA2-deficient cell lines, such as VC8 (Chinese hamster transformed lung fibroblasts) and Peo1 (human ovarian carcinoma), paired with their respective counterparts in which BRCA2 expression was restored. Here, BRCA2 is linked to colonic neoplasm.