The purpose of the present study was to use multiparametric CMR and other methods applied to an HFHSD mouse model of obesity-induced MHD to investigate the effects of preventive SGLT2 inhibition on EAT quantity and quality, macrophages, coronary microvascular dysfunction, and diastolic dysfunction. Here, SLC5A2 is linked to obesity due to melanocortin 4 receptor deficiency.