Epigenetic profiling showed global hypomethylation in PMS cells, particularly at promoters regulated by inflammatory TFs, including STAT6 and NF-κB, mirroring patterns observed in aging tissues.92 These epigenetic changes, associated with aging and genome instability,92 were also found in PMS fibroblasts, indicating persistent, disease-associated epigenetic dysregulation. The gene discussed is NFKB1; the disease is premenstrual tension.