However, three SNPs showed some weak evidence of an effect on PRS in the opposite direction to their effect on cleft lip phenotypes: rs62390705 (FBN2, 5q23.3) (P = 0.05), rs126280 (UTP25, 1q32.2) (P = 0.002), and rs4952552 (PKDCC, 2q14.2) (P = 0.04). This evidence concerns the gene FBN2 and cleft lip.