μCT scans further revealed that the scarcity of CD19+ cells in the central regions of the metaphysis correlated with a loss of trabecular bone in that region (Figure 4A, insert; Figure S3B), consistent with previous reports that B6 mice develop severe senile osteoporosis (Glatt et al. 2007; Halloran et al. 2002; Xu et al. 2021). The gene discussed is CD19; the disease is osteoporosis.