IDH1 and central nervous system cancer: Beyond IDH status, molecular stratification within IDHwt gliomas according to the current WHO classification demonstrates that histologically lower-grade gliomas (WHO grade 2 and 3) with a molecular GB-like profile (molecular GB IDHwt) exhibit a significantly higher incidence of GAE before diagnosis and a longer interval between seizure onset and tumor detection compared to classical IDHwt GB, suggesting a distinct clinical trajectory [16].