In contrast, a warning about liver dysfunction under the “Clinically Significant Adverse Reactions” (CSAR) section in Japanese PIs varies among ACE inhibitors; i.e., the warning is included for enalapril maleate, lisinopril hydrate, benazepril hydrochloride, temocapril hydrochloride and trandolapril but not for the others, although liver dysfunction is usually mentioned under the “Other Adverse Reactions” section [3]. Here, ACE is linked to Decreased liver function.