MAPT and Alzheimer disease: Mechanistic studies in mice and biomarker studies in humans have clearly demonstrated the importance of glia activation and neuroinflammation for disease progression in different AD stages for tau spreading, Aβ accumulation and neurodegeneration (Serrano-Pozo et al, 2024; Habib et al, 2020; Shen et al, 2019; Heneka et al, 2025b; Heneka, 2017; Venegas et al, 2017; Foley et al, 2024).